...treatment with a patch delivering 300 µg of testosterone per day resulted in a modest but meaningful improvement in sexual function.
Testosterone for Low Libido in Postmenopausal Women Not Taking Estrogen
Not Taking Estrogen エストロゲン治療を受けていない
Background The efficacy and safety of testosterone treatment for hypoactive sexual desire disorder in postmenopausal women not receiving estrogen therapy are unknown.
not receiving estrogen therapy エストロゲン療法を受けていない
Methods We conducted a double-blind, placebo-controlled, 52-week trial in which 814 women with hypoactive sexual desire disorder were randomly assigned to receive a patch delivering 150 or 300 µg of testosterone per day or placebo. Efficacy was measured to week 24; safety was evaluated over a period of 52 weeks, with a subgroup of participants followed for an additional year. The primary end point was the change from baseline to week 24 in the 4-week frequency of satisfying sexual episodes.
conducted a trial トライアルを実施した
were randomly assigned 無作為に割り付けた
for an additional year 更に１年間
Results At 24 weeks, the increase in the 4-week frequency of satisfying sexual episodes was significantly greater in the group receiving 300 µg of testosterone per day than in the placebo group (an increase of 2.1 episodes vs. 0.7, P<0.001) but not in the group receiving 150 µg per day (1.2 episodes, P=0.11). As compared with placebo, both doses of testosterone were associated with significant increases in desire (300 µg per day, P<0.001; 150 µg per day, P=0.04) and decreases in distress (300 µg per day, P<0.001; 150 µg per day, P=0.04). The rate of androgenic adverse events ― primarily unwanted hair growth ― was higher in the group receiving 300 µg of testosterone per day than in the placebo group (30.0% vs. 23.1%). Breast cancer was diagnosed in four women who received testosterone (as compared with none who received placebo); one of the four received the diagnosis in the first 4 months of the study period, and one, in retrospect, had symptoms before undergoing randomization.
were associated with significant increases in ～における有意な増加と関連していた
as compared with none who received placebo それに対してプラセボ群ではいなかった
in retrospect 振り返って考えれば
Conclusions In postmenopausal women not receiving estrogen therapy, treatment with a patch delivering 300 µg of testosterone per day resulted in a modest but meaningful improvement in sexual function. The long-term effects of testosterone, including effects on the breast, remain uncertain.
resulted in ～という結果であった
remain uncertain 不明なままである
NEJMのサイトはThe New England Journal of Medecineで見られます。abstractは無料で閲覧できますから、どうぞ。