Welcome to the New England Journal of Medicine audio summary for the weekThis summary covers the issue of July 22, 2010. I'm Dr Lisa Johnson. This week's issue featuresFeatured are articles on sensor-augmented insulin-pump therapy in type 1 diabetes, prediction of lung functioncancer, treatment for acute ACL tears, molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis, and efficacy of gene therapy for X-linked severe combined immunodeficiency; a review article on functional hypothalamic amenorrhea; a case report of a woman with dementia and a seizure; and Perspective articles on the path to personalized medicine, on the ACA’s new weapons against health care fraud, and on cancer clinical trials, a chronic but curableapproaching a state of crisis.This issue features a new video in clinical medicine, demonstrrating clinical evaluation of the knee. Knee problems are one of the most priminet muscular-skeltal symptoms evaluated by the primary care position. This video shows how to perform comprehensive examination of the knee.