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Welcome to the New England Journal of Medicine audio summary for the week of December 4, 2008. I'm Dr. Michael Bierer. This week's issue featuresThis summary covers the issue of December 4, 2008. Featured are articles on benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients, prolonged therapy of advanced chronic hepatitis C with low-dose peginterferon, tenofovir disoproxil fumarate versus adefovir dipivoxil for chronic hepatitis B, and irbesartan in patients with heart failure and preserved ejection fraction, and proteinuria and immunity; a review article on treatment ofon levodopa for Parkinson’s disease with levodopa; a Clinical Problem-Solving article describing a patient with arthralgia, anemia and severedepression, mitral-valve prolapse, and migraine headaches; a clinical implications of basic research article on cyclosporine and podocyte; and Perspective articles abouton bringing primary care forto the housebound elderly and on circumcision as a surgical strategy for HIV prevention in Africa.