Welcome to the New England Journal of Medicine audio summary for the weekThis summary covers the issue of September 16, 2010. I'm Dr Michael Bierrer. This week's issue feateresFeatured are articles on neuromuscular blockers in early ARDS, JAK1 and JAK2 inhibition in myelofibrosis, susceptibility to exacerbation in COPD, smoke-free legislation and childhood asthma, and darbepoetin and kidney disease; a review article on idiopathic urgency urinary incontinence; a case report of a woman, 3 weeks post partum, with substernal chest pain; and Perspective articles on the safety of tiotropium, on preparing for a consumer-driven genomic age, on the risks of presymptomatic direct-to-consumer genetic testing, and on "Liberating the NHS" another attempt to implement market forces in English health care. At NEJM.org, every issue of the journal is now available in electronic form all the way back to the first article, "Remarks of Angina Pectoris" by John Warren, published in January, 1812. The entire archive consists of 8498 issues and is fully searchable. We hope that readers will find the new digital archive useful and informative.